By R. Süss, V. Kinzel, J. D. Scribner (auth.)
This publication particularly must be learn on holiday, only for amusement. Granted, melanoma is, actually, a dangerous critical topic, and melanoma learn is essentially part of drugs with Hippocrates in its again flooring. but, melanoma examine is additionally normal technological know-how, and as such it yields the fun and sorrows of any technology. The melanoma challenge is usually a mind teaser, a problem for the curious. This introductory record on experimental melanoma examine is there fore directed to curious scholars of many disciplines: obviously to scientific scholars, but additionally to chemists and physicists who've an curiosity in organic phenomena; biology scholars would certainly en counter pr9blems bizarre to their box in what's supposedly a medi cal one. we now have tried to write down with out assumptions to a undeniable measure, for a chemist is basically in over his head in drugs, and a doctor has merely the slightest thought of the chemical difficulties im portant in melanoma learn. We had no purpose of giving an entire view of the sector, and from the massive variety of assorted traces of improvement we've got selected just a couple of. Chemotherapy, as an ex plentiful, has been handled rather cursorily, in addition to RNA tumor viruses, even though it is feasible that simply those matters are specially vital for human tumors. Tumor induction through radiation may possibly merely be pointed out in passing, regardless of its nice sensible value; equally the function of hormones used to be in basic terms intimated.
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Which Esters are the "Ultimate Carcinogens"? Besides the easily prepared benzoate and acetate esters, sulfate esters were also prepared. All three esters of N-OH-AAF reacted in vitro with methionine, especially the sulfate. King and Phillips then performed experiments with liver homogenates which seemed to show that both phosphate and sulfate esters are formed, but the Millers could confirm only the formation of sulfates. DeBaun and the Millers then did a detailed study of the "sulfotransferase" system, establishing its existence beyond reasonable doubt and revealing more of its detailed characteristics.
The loss of these proteins would then directly cause uncontrolled growth into tumors. Treatment of cell cultures with h-protein preparations did lead to reversible growth inhibition. However, contaminating arginase was found to be the active principle, by removing the arginine necessary for cell growth. Carcinogenic aromatic amines react not only with protein, but also with nucleic acids. The binding to DNA is now believed to be a decisive step for carcinogenesis. A CLOSER LOOK AT CHEMICAL CARCINOGENESIS: QUANTITATIVE ASPECTS "I contend, however, that in each particular natural theory there is only so much real science as there is mathematics," said Kant years before Lord Kelvin.
Carcinogenicity and protein binding are well correlated, and the h-proteins are severely reduced in hepatomas. The "deletion hypothesis" requires that the h-proteins have a growth-regulating effect. The loss of these proteins would then directly cause uncontrolled growth into tumors. Treatment of cell cultures with h-protein preparations did lead to reversible growth inhibition. However, contaminating arginase was found to be the active principle, by removing the arginine necessary for cell growth.