By M. E. Drets, G. A. Folle, F. J. Monteverde (auth.), Professor Dr. Günter Obe, Professor Dr. A. T. Natarajan (eds.)
Chromosomale Mutationen sind eine der m|glichen Ursachen f}r Ver{nderungen der Erbinformation. Neben grunds{tzlichen As- pekten, wie Reparaturmechanismen der Zelle oder Ursachen von Chromosomenver{nderungen, werden angewandte Aspekte, z.B. Chromosomen als Testindikatoren der Toxizit{t, behandelt.
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6 Poly-ADP-Ribosylation System: a Protein Shuttle Mechanism in Chromatin? . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 22 23 23 26 27 27 29 1 Introduction The poly-ADP-ribosylation system of higher eukaryotes is thought to modulate chromatin functions. The molecular mechanism of this presumed action is unknown (for review see Althaus and Richter 1987).
Mutat Res 177: 149-160 Darroudi F, Natarajan AT (1989a) Cytological characterization of Chinese hamster ovary X-ray sensitive mutant cells xrs 5 and xrs 6. VII. Complementation analysis of X-irradiated wild type CHO-Kl and xrs mutants using premature chromosome condensation technique. Mutat Res 213: 249-255 Darroudi F, Natarajan AT (1989b) Cytogenetical characterization of Chinese hamster ovary X-ray sensitive mutant cells xrs 5 and xrs 6. III. Induction of cell killing, chromosomal aberrations and sister chromatid exchanges by bleomycin, mono- and bi-functional alkylating agents.
Exchanges were also classified as interchanges (between different chromosomes), interarm exchanges (between different arms of the same chromosome), and intraarm. The intra-arm exchanges were classified as dot deletions, sister unions, and proximal-distal interchromatid exchanges (see Fig. 2). The numbers of the different types are shown in Table 1. The dose-yield relationships for interchromosomal exchanges and intrachromosomal exchanges is shown in Fig. 3. 0032/Gy2. Clonogenic survival of cells irradiated in G 2, with and without colcemid treatment, is shown in Fig.